Ivan Ufimtsev and Todd Martínez at the University of Illinois at Urbana-Champaign have implemented an efficient method of calculating two-electron repulsion integrals over Gaussian basis functions on the GPU. Virtually all modern quantum chemical calculations require evaluating millions to billions of these integrals. This problem turns out to be well-suited to the massively parallel architecture of GPUs by an appropriate partitioning of the problem. A benchmark test performed for the evaluation of approximately one million (ss|ss) integrals over contracted s-orbitals showed that a naïve algorithm implemented on the GPU achieves up to 130-fold speedup over a traditional CPU implementation on an AMD Opteron. Subsequent calculations on a 256-atom DNA strand show that the GPU advantage is maintained for basis sets including higher angular momentum functions. (Quantum Chemistry on Graphical Processing Units. 1. Strategies for Two-Electron Integral Evaluation, Ivan S. Ufimtsev and Todd J. Martínez, J. Chem. Theory Comput., 4 (2), 222 -231, 2008. doi:10.1021/ct700268q)